[5] Pocognoli made his Genk debut, where he came on as a substitute for Marco Ingrao in the second half, in a 1–0 win over Gent on 9 April 2004, which turns out to be his own appearance this season.[3] At the end of the 2006–07 season, Pocognoli was nominated for the Young Player Footballer of the Year award, but lost out to Lucas Biglia.[18] Pocognoli made his AZ Alkmaar debut, where he came on as a substitute in the second half, in a 4–0 win over VVV-Venlo in the opening game of the season.[19] Pocognoli then scored his first goal for the club, in the UEFA Cup match, in a 1–0 win over Paços de Ferreira on 20 September 2007.[20] Pocognoli scored his first league goal for the club on 9 December 2007, in a 2–1 win over Utrecht[21] and his second later came on 22 January 2008, in a 2–1 loss against NAC Breda.[29] Despite this, he helped the club win the league for the first time since 1981 after title contender Ajax lost 6–2 to PSV Eindhoven on 18 April 2009.[33] However, his first team opportunities was limited under the new management of Ronald Koeman, due to injury[34] and spent most of the first half of the season on the substitute bench.[81] Pocognoli finally made his first league appearance of the season, and set up Salomón Rondón to score the only goal, in a 1–0 win over Manchester United on 6 March 2016.On 30 August 2016, Pocognoli joined Football League Championship club Brighton & Hove Albion on a season-long loan deal following an injury to first-choice left-back Liam Rosenior.[83] Competing with Gaëtan Bong for the left–back spot,[84] Pocognoli made his Brighton & Hove Albion debut in a 0–0 draw against Ipswich Town on 27 September 2016, playing the full match.[88] On 17 March 2018, he played as Standard Liege beat Genk 1–0 in extra time to win the 2018 Belgian Cup Final and qualify for the UEFA Europa League.[92] While playing for the national team in 2009, Pocognoli was involved in a dressing room altercation with teammates Timmy Simons and Stijn Stijnen.