Rickettsia conorii
Rickettsia conorii is a Gram-negative, obligate intracellular bacterium of the genus Rickettsia that causes human disease called boutonneuse fever, Mediterranean spotted fever, Israeli tick typhus, Astrakhan spotted fever, Kenya tick typhus, Indian tick typhus, or other names that designate the locality of occurrence while having distinct clinical features.[3][4] It is a member of the spotted fever group and the most geographically dispersed species in the group, recognized in most of the regions bordering on the Mediterranean Sea and Black Sea, Israel, Kenya, and other parts of North, Central, and South Africa, and India.The bacterium was isolated by Emile Brumpt in 1932[5] and named after A. Conor, who in collaboration with A. Bruch, provided the first description of boutonneuse fever in Tunisia in 1910.[7][8][9][10][11] Genomes of intracellular or parasitic bacteria undergo massive reduction compared to their free-living relatives.[12] Some of the largest virions like Megavirus chilense, Pandoravirus, Pithovirus and Mimivirus are comparable in size to miniature bacteria like T. whipplei and Rickettsia conorii.