Reverse tolerance
This is the opposite of drug tolerance, in which the effect or the subject's reaction decreases following its repeated use.[5] Sensitization, a form of reverse tolerance, develops rapidly to the positive, euphoric effects of alcohol, but not to the physical effects, such as sedation and respiratory depression, which diminish with prolonged use.This sensitization does not occur, however, with administration of benzodiazepines or neuroactive steroids, which only exhibit weakening of effect with repeated use.Reverse tolerance can also occur in users of stimulants such as cocaine or amphetamines.A previously recreational dose may become enough to cause psychosis in regular users, or users who previously had a psychotic episode may be more likely to have one in the future and at lower doses once drug usage continues.