Phthalylsulfathiazole
Phthalylsulfathiazole (also known as sulfathalidine)[1] is a sulfonamide broad-spectrum antimicrobial used primarily for treating gastrointestinal infections.[3] Phthalylsulfathiazole is typically given orally in tablet form to target intestinal infections directly.[2] Due to the phthalic acid substitution on the aniline nitrogen, it remains unabsorbed in the bloodstream, focusing its action within the gut.This inhibition disrupts purine and pyrimidine synthesis, impairing bacterial growth and reproduction.[8] Once in the large intestine, phthalylsulfathiazole hydrolyzes to release sulfathiazole, the active antimicrobial component.