POU3F4
545618994ENSG00000196767ENSMUSG00000056854P49335P62515NM_000307NM_008901NP_000298NP_032927POU domain, class 3, transcription factor 4 is a protein that in humans is encoded by the POU3F4 gene found on the X chromosome.[5][6][7] POU3F4 is involved in the patterning of the neural tube and both the paraventricular and supraoptic nuclei of the hypothalamus in the developing embryo.[9] A “knockout” mice model displayed that alteration to the POU3F4 gene interrupted this mesenchymal cell differentiation in the superior semicircular canal.[11] These known mutations include: Physical anomalies caused by POU3F4 mutations that have been recognized by high resolution computed tomography (HRCT) and magnetic resonance imaging (MRI) include absence of the central axis of the cochlea, an abnormally wide lateral internal auditory canal and a thickened stapes footplate.[15] This article incorporates text from the United States National Library of Medicine, which is in the public domain.