ARHGEF1

1IAP, 1SHZ, 3AB3, 3ODO, 3ODW, 3ODX, 3P6A913816801ENSG00000076928ENSMUSG00000040940Q92888Q61210NM_004706NM_198977NM_199002NM_001130150NM_001130151NM_001130152NM_001130153NM_008488NP_004697NP_945328NP_945353NP_001123622NP_001123623NP_001123624NP_001123625NP_032514Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ARHGEF1 gene.[5] Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide GDP.[8] In particular, active Rho is a major regulator of the cell actin cytoskeleton.This action increases the rate of G protein deactivation, limiting the time during which these RhoGEFs activate Rho.[7] ARHGEF1 has been shown to interact with: This article on a gene on human chromosome 19 is a stub.
AliasesHomoloGeneGeneCardsChromosome 19 (human)RNA expressionGene ontologyOrthologsEntrezEnsemblUniProtPubMedWikidataproteinguanine nucleotide exchange factorsmall GTPaseguaninenucleotideeffectorenzymescytoskeletonRhoGEFG protein coupled receptorsG12 and G13heterotrimeric G proteinsARHGEF11ARHGEF12AKAP13RGS familyGTPase-activating proteins (GAPs)interactP110αSecond messenger systemG protein-coupled receptorHeterotrimeric G proteinSmall GTPasesRho family of GTPasesUCSC Genome Browserchromosome 19