Because her mother died when she was only seven, she was brought up by Anne de Beaujeu,[1] who was regent of France for her brother Charles VIII.At Amboise she met Margaret of Austria (daughter of Maximilian and Mary of Burgundy), who was betrothed to the young king and with whom Louise would negotiate peace several decades later.[5] When she was widowed at the young age of 19, Louise deftly manoeuvred her children into a position that would secure for each of them a promising future.Though they remained in Cognac for two years,[6] she moved her family to court at the ascension of King Louis XII, her husband's cousin.Louise had a keen awareness of the intricacies of politics and diplomacy, and was deeply interested in the advances in arts and sciences in Renaissance Italy.[7] When Louis XII became ill in 1505, he determined that Francis should succeed him and that both Louise and his wife Anne of Brittany should be part of the regency council.[9] In December 1525, a second mission was sent, led by John Frangipani, which managed to reach Constantinople, the Ottoman capital, with secret letters asking for the deliverance of King Francis I and an attack on the Habsburg.