Joel Sussman

Joel L. Sussman (born September 24, 1943) is an Israeli crystallographer best known for his studies on acetylcholinesterase, a key protein involved in transmission of nerve signals.In 1994–99, he was also the director of the Protein Data Bank (PDB) at the Brookhaven National Laboratory.Sussman was a pioneer of macromolecular refinement, developing CORELS and applying it to yeast tRNAphe.[3] Sussman's current research focuses on nervous system proteins, especially acetylcholinesterase (AChE), whose 3D structure was first determined in his lab.This structure revealed: He has investigated the molecular basis as to how proteins function under extreme conditions [8][9] with unexpected implications for kidney diseases.
Cornell UniversityHebrew UniversityacetylcholinesteraseWeizmann Institute of SciencecrystallographerproteinWeizmann InstituteRehovotPhiladelphiaPennsylvaniabiophysicsCyrus LevinthalHebrew University of JerusalemYehuda LapidotDuke UniversitySung-Hou KimProtein Data BankBrookhaven National Laboratoryα/β hydrolase foldπ-cation interactionsacetylcholineligandscytoplasmiccholinesterasesynchrotron radiationGlucocerebrosidaseGaucher diseaseparaoxonaseatherosclerosisHermona SoreqChinese Academy of SciencesEuropean Molecular Biology OrganizationScience