JWH-363
JWH-363 (1-Naphthyl{1-pentyl-5-[3-(trifluoromethyl)phenyl]-1H-pyrrol-3-yl}methanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as an agonist of the CB1 (Ki = 245 ± 5nM) and CB2 (Ki = 71 ± 1nM) receptors, with a moderate (~3.45x) selectivity for the latter.JWH-363 was first synthesized in 2006 by John W. Huffman and colleagues to examine the nature of ligand binding to the CB1 receptor.[1] In the United States JWH-363 is not federally scheduled, although some states have passed legislation banning the sale, possession, and manufacture of JWH-363.[2][3][4][5] In Canada, JWH-363 and other naphthoylpyrrole-based cannabinoids are Schedule II controlled substances under the Controlled Drugs and Substances Act.In the United Kingdom, JWH-363 and other naphthoylpyrrole-based cannabinoids are considered Class B drugs under the Misuse of Drugs Act 1971.
Legal statusIUPAC nameCAS NumberChemSpiderCompTox DashboardFormulaMolar massSMILESsynthetic cannabinoidJohn W. HuffmanCB1 receptorControlled Drugs and Substances ActMisuse of Drugs Act 1971List of JWH cannabinoids21 U.S.C.CannabinoidscomparisonCBD-C1Delta-8-THCDelta-9-THCDelta-10-THC7,8-Dihydrocannabinol8,9-DihydrocannabidiolCannabicitranCaryophylleneAlkylamidesEpigallocatechin gallateGallocatecholHexahydrocannabinolPerrottetineneSerinolamide AYangonin3'-OH-THC7-OH-CBD8,11-DiOH-THC11-COOH-THC11-OH-CBN11-OH-HHC11-OH-Δ8-THC11-OH-Δ9-THCEndocannabinoidsArachidonoyl ethanolamide (AEA; anandamide)2-Arachidonoylglycerol (2-AG)2-Arachidonyl glyceryl ether (2-AGE; noladin ether)2-Oleoylglycerol (2-OG)N-Arachidonoyl dopamine (NADA)N-Arachidonylglycine (NAGly)N-Arachidonoyl serotonin (AA-5-HT)Docosatetraenoylethanolamide (DEA)Lysophosphatidylinositol (LPI)OleamideOleoylethanolamide (OEA)Palmitoylethanolamide (PEA)RVD-HpαStearoylethanolamide (SEA)O-Arachidonoyl ethanolamine (O-AEA; virodhamine)Syntheticcannabinoidreceptoragonists /neocannabinoids1,2-Didehydro-3-oxo-THCO9-OH-HHC9-Nor-9β-HHCA-40174A-41988Ajulemic acidAM-087AM-411AM-855AM-905AM-906AM-919AM-926AM-938AM-2389AM-4030AM-7438AM-11245AMG-36AMG-41CP 42,096Delta-3-THCDelta-4-THCDelta-7-THCDexanabinol (HU-211)DronabinolHU-210HU-243JWH-051JWH-057JWH-091JWH-124JWH-130JWH-133JWH-138JWH-142JWH-143JWH-161JWH-359KM-233L-759,633L-759,656Levonantradol (CP 50,5561)MenabitanNabazenilNabidrox (Canbisol)NabiloneNabitanNaboctateO-1057O-1125O-1238O-2113O-2372O-2545O-2694ParahexylPirnabineSP-111THC hemisuccinateTHC-O-acetateTHC-O-phosphateCannabicyclohexanolCannabinorCBD-DMHCP 47,497(C6)-CP 47,497(C9)-CP 47,497