Isadora is an unincorporated community in northwest Worth County, Missouri, United States.The community is on the floodplain of the Grand River and is three miles (4.8 km) south of the Missouri–Iowa state line.[3] A post office called Isadora was established in 1866, and remained in operation until 1951.[4] According to tradition, the community was named after the wife of a pioneer man who paid a visit to the area.This Worth County, Missouri state location article is a stub.