Gold-containing drugs
[1] Research on the medicinal effects of gold began in 1935,[2] primarily to reduce inflammation and to slow disease progression in patients with rheumatoid arthritis.The use of gold compounds has decreased since the 1980s because of numerous side effects and monitoring requirements, limited efficacy, and very slow onset of action.A noticeable side-effect of gold-based therapy is skin discoloration, in shades of mauve to a purplish dark grey when exposed to sunlight.Chrysiasis can ultimately lead to acute kidney injury (such as tubular necrosis, nephrosis, glomerulitis),[8] severe heart conditions, and hematologic complications (leukopenia, anemia).Other side effects of gold-containing drugs include kidney damage, itching rash, and ulcerations of the mouth, tongue, and pharynx.
Sodium aurothiomalateAuranofinpharmaceuticalsinflammationdiseaserheumatoid arthritismetal thiolate complexesgold cyanideMycobacterium tuberculosisproteinkidneyblood testschrysiasisargyriaacute kidney injuryDisodium aurothiomalateSodium aurothiosulfatethiosulfatethiomalateAurothioglucoseUniversity of WashingtonantirheumaticQuinolinesOxycinchophenGold preparationsAurotioprolPenicillamineBucillamineChloroquineHydroxychloroquineLeflunomideSulfasalazineantifolateMethotrexatethiopurineAzathioprineWHO-EMWithdrawnClinical trials