Glucose transporter
Because glucose is a vital source of energy for all life, these transporters are present in all phyla.In Saccharomyces cerevisiae glucose transport takes place through facilitated diffusion.[9][10] Each glucose transporter isoform plays a specific role in glucose metabolism determined by its pattern of tissue expression, substrate specificity, transport kinetics, and regulated expression in different physiological conditions.In August 1960, in Prague, Robert K. Crane presented for the first time his discovery of the sodium-glucose cotransport as the mechanism for intestinal glucose absorption.This hypothesis was rapidly tested, refined, and extended [to] encompass the active transport of a diverse range of molecules and ions into virtually every cell type.
InterProPROSITEOPM superfamilyOPM proteinPDBsumGlucosemembrane proteinsplasma membranefacilitated diffusionprotein familymammalian cellshuman genomeuniporterautotrophicglucose-6-phosphataseuptakecatabolismhepatocytesgluconeogenesisSaccharomyces cerevisiaerepressorsporulationgalactosehelicescarboxyl terminicytoplasmichexosessubstrateconformational changeisoformerythrocytesendothelialblood–brain barrierrespirationrenal tubularbeta cellsepitheliumglycolysisglycogenesismonosaccharidesfructosemucosalportal circulationneuronsplacentaadipose tissuesstriated muscleskeletal musclecardiac muscleinsulinGLUT14enterocytesendoplasmic reticulumuric acidGLUT11GLUT10GLUT12GLUT13myo-inositolgenome projectsPragueRobert K. Cranecotransportbrush borderCotransporterGLUT1 deficiency syndromeGLUT2 deficiency syndromeBibcodeCrane RKCzech Academy of SciencesRobert CraneMedical Subject Headingscarrier proteinsmembrane transport proteinssolute carrierhigh affinity glutamate and neutral amino-acid transporterSLC1A1SLC2A1heterodimeric amino-acid transportersSLC3A1bicarbonate transporterSLC4A1sodium glucose cotransporterSLC5A1sodiumchlorideSLC6A1SLC6A2SLC6A3SLC6A4SLC6A5SLC6A6SLC6A8SLC6A9SLC6A11SLC6A12SLC6A13SLC6A14SLC6A15SLC6A18SLC6A19SLC6A20SLC7A1SLC7A2SLC7A3SLC7A4SLC7A5SLC7A6SLC7A7SLC7A8SLC7A9SLC7A10SLC7A11SLC7A14Na+/Ca2+ exchangerSLC8A1Na+/H+ exchangerSLC9A1SLC9A2SLC9A3SLC9A5SLC9A6SLC9A8SLC9A10SLC9A11SLC10A1