Both his life and his career can be divided into four distinct periods, which correspond to the four cities in which he would live and work, Piacenza, Milan, Parma, and Turin.During this time a few of his instruments bear labels implying a relationship to Cremona—the home of the renowned violin makers Amati, Stradivari, and Guarneri—however no evidence exists that Guadagnini ever lived in Cremona.He may have been drawn to the city by the recent appointment of Carlo Ferarri, a close musician friend from his time in Piacenza, to a position with the Ducal Court.[6] During his time in Parma Guadagnini was also closely connected to the court, and in particular to the musical patronage of the Prime Minister Guillaume du Tillot.His work in each new city changed in response to the availability of materials, the needs of the local musicians, and finally in Turin, his relationship with Count Cozio.