Forskolin

Forskolin (coleonol) is a labdane diterpene produced by the plant Coleus barbatus (blue spur flower).Forskolin is commonly used in laboratory research to increase levels of cyclic AMP by stimulation of adenylate cyclase.It is required for cell communication in the hypothalamus-pituitary gland axis, and for the feedback control of hormones via induction of corticotropin-releasing factor gene transcription.It is defined as a category 4 chemical with acute dermal toxicity based on 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200).Although forskolin has been used in preliminary weight loss research, the low quality of the studies and inconclusive results prevented any determination of effects.