Enoxolone
Cortisol has intrinsic mineralocorticoid properties (that is, it acts like aldosterone and increases sodium reabsorption) that work on ENaC channels in the collecting duct.[citation needed] The increased amounts of cortisol binds to the unprotected, nonspecific mineralocorticoid receptors and induce sodium and fluid retention, hypokalaemia, high blood pressure, and inhibition of the renin-angiotensin-aldosterone system.[12] When R is an anionic NHCO(CH2)CO2K side chain, the sweetening effect is found to be 1200 times that of sugar (human sensory panel data).In addition, the sweetener molecule requires three proton donor positions, of which two reside at the extremities, to be able to interact efficiently with the receptor cavity.Acetoxolone, the acetyl derivative of glycyrrhetinic acid, is a drug used in the treatment of peptic ulcer and gastroesophageal reflux disease.
Drugs.comRoutes ofadministrationATC codeD03AX10Legal status℞-onlyIUPAC nameCAS NumberDrugBankChemSpiderChEMBLCompTox DashboardECHA InfoCardFormulaMolar massSMILEStriterpenoidbeta-amyrinhydrolysisglycyrrhizic acidliquoriceflavoringquininebenzocainechlorhexidineSalonpasdermatosespeptic ulcerexpectorantenzymes15-hydroxyprostaglandin dehydrogenaseprostaglandinsmetabolitespancreaticintestinesstomachgastric acidcortisoneanti-inflammatorycortisolkidneys11-β-hydroxysteroid dehydrogenasealdosteronesodiumHypertensionhypokalaemiafunctional grouphydroxylartificial sweeteneranionicside chaintaste budreceptornanometersangstromsprotoncarbenoxolonegap junctionAcetoxoloneacetylgastroesophageal reflux disease11α-HydroxyprogesteroneWayback MachinewoundsulcersCicatrizantsepichlorohydrinCadexomer iodineCrilanomerDextranomerCalcium pantothenateDexpanthenolnitrateNitroglycerinIsosorbide dinitrateBecaplerminBeremagene geperpavecBetulae cortexCentella asiatica herbaHyaluronic acidKetanserinNepiderminSodium chlorite (tetrachlorodecaoxide)TraferminTrolamineBromelain (anacaulase)ClostridiopeptidaseTrypsinGlucocorticoid receptormodulatorsAgonists3α,5α-Tetrahydrocorticosterone5α-Dihydrocorticosterone9α-Fluorocortisone (alfluorone)11-Dehydrocorticosterone (11-oxocorticosterone, 17-deoxycortisone)11-Deoxycorticosterone (desoxycortone, deoxycortone, desoxycorticosterone)11-Deoxycortisol (cortodoxone, cortexolone)Cortifen (cortiphen, kortifen)21-DeoxycortisolΔ7-PrednisoloneAmebucortChloroprednisoneChloroprednisone acetateCloprednolCorticosteronehydrocortisoneBenzodrocortisone (hydrocortisone benzoate)Hydrocortamate (hydrocortisone diethylaminoacetate)Cortisone acetateDeprodoneDichlorisoneDifluprednateEndrisone (endrysone)EtiprednolFludrocortisone (fludrocortone)Fludrocortisone acetateFluorometholoneFluorometholone acetateFluperoloneFluperolone acetateFluprednisoloneHalopredoneIsoflupredone (9α-fluoroprednisolone)LoteprednolMazipredone (depersolone)Medrysone