Dermal fibroblast
[1] Using organelles (particularly the rough endoplasmic reticulum), dermal fibroblasts generate and maintain the connective tissue which unites separate cell layers.Based on evidence of α-SMA expression from lung injuries, myofibroblasts can "arise de novo" directly from mesenchymal stem cells.[4] Dermal fibroblasts are responsible for creating the ECM which organizes the stratified squamous epithelial cells of the epidermis into a unified tissue.[6] When the body sustains a third degree burn, the skin's dermal layer is completely destroyed by heat (and the all fibroblast cells within the wound site perish).[7] As noted "The injured dermis is also repaired by the recruitment and proliferation of fibroblasts producing extracellular matrix and keratinocyte growth promoting factors.[6] FGF-1 has been experimentally shown to encourage the body’s own adhesive tissue to develop and effectively seal the wound (thereby stymieing infection and mitigating scar formation).By generating adhesive proteins like fibronectin, fibroblasts are used within research laboratories to help to culture cells which typically demonstrate low survival rates in vitro.