Bisio was born in Novi Ligure, Piedmont, and raised in Milan, Lombardy.[3] In 2009, he played in Ex and gained a David di Donatello nomination for best supporting actor.[4] In 2010 he was the protagonist of Benvenuti al Sud (Welcome to the South) and Maschi contro femmine (Males vs Females) and in 2011 of Benvenuti al Nord (Welcome to the North) and Femmine contro maschi (Females vs Males).In the Italian version of the Ice Age series, Bisio is the voice of Sid (one of the protagonists of the film).In the summer of 2014 has been announced he will be part of Italia's Got Talent jury for its sixth series, aired in 2015 by the pay-TV Sky Uno.