Cherry Run is a small unincorporated community hamlet located along the CSX Transportation (formerly Baltimore and Ohio Railroad) mainline on the Potomac River in Morgan County in the U.S. state of West Virginia.It was originally known as Cherry Run Depot because of the important interchange between the B&O and the Western Maryland Railway located there.The tower was closed in September 2000, disassembled, and moved to the Martinsburg Shops site in February 2001.Across the Potomac from Cherry Run lies Big Pool on the Chesapeake and Ohio Canal.On the B&O mainline, Cherry Run is located between Hancock to its west and Little Georgetown in Berkeley County to its east.