Cartilage associated protein
[5] CRTAP forms a tight protein complex with two other enzymes involved in post-translational modification: Leprecan (P3H1) and PPIB.[7] In this complex, CRTAP acts as a collagen-binding site, capturing substrates for subsequent enzymatic processing by P3H1 and PPIB.Notably, CRTAP exhibits a folding pattern similar to the N-terminal domain of P3H1.Mutations in the CRTAP gene are associated with osteogenesis imperfecta, types VII and IIB, a connective tissue disorder characterized by bone fragility and low bone mass.[8][9] This article incorporates text from the United States National Library of Medicine, which is in the public domain.