CYP2C8
2VN0, 1PQ2, 2NNH, 2NNI, 2NNJ155813098ENSG00000138115ENSMUSG00000025003P10632P56656NM_000770NM_001198853NM_001198854NM_001198855NM_030878NM_010003NM_001373937NP_000761NP_001185782NP_001185783NP_001185784NP_034133NP_001360866Cytochrome P4502C8 (CYP2C8) is a member of the cytochrome P450 mixed-function oxidase system involved in the metabolism of xenobiotics in the body.[5] Following is a table of selected substrates, inducers and inhibitors of 2C8.Inhibitors of CYP2C8 can be classified by their potency, such as: Strong Moderate Unspecified potency Unspecified potency Where classes of agents are listed, there may be exceptions within the class.CYP2C8 also possesses epoxygenase activity: it is one of the principal enzymes responsible for attacking various long-chain polyunsaturated fatty acids at their double (i.e. alkene) bonds to form epoxide products that act as signaling agents.[9][10][11] Along with CYP2C8, CYP2C9, CYP2C19, CYP2J2, and possibly CYP2S1 are the main producers of EETs and, very likely, EEQs, EDPs, and the epoxides of linoleic acid.