Borna disease
Borna disease is a severe neurological illness that predominantly affects horses and sheep, but it has been observed in a wide range of mammals.Borna diseases viruses 1 and 2 appear to have wide host ranges, having been detected in horses, cattle, sheep, new world camelids, dogs, cats, and foxes.[citation needed] Symptoms of Borna disease in horses and sheep start after a four-week incubation period followed by the development of immune-mediated meningitis and encephalomyelitis.[citation needed] Clinical manifestations vary but may include excited or depressed behaviour, ataxia, teeth grinding, excessive salivating, ocular disorders and abnormal posture and movement.Earlier research with purified avian bornavirus inoculant (while did result in the death of parrots) did not reproduce histopathological changes associated with PDD.[4][23] In 1990, Janice E. Clements and colleagues reported in the journal Science that antibodies to a protein encoded by the BoDV-1 genome are found in the blood of patients with behavioral disorders.