Blaschko's lines
Similar to Blaschko, he suggested that the linear patterns of nevi followed "streams" of tissue growth that occurred during embryogenesis rather than being related to an epidermal structure.[15] In 1945, the Journal of Heredity published Russian scientist Moisey Davidovich Zlotnikov's research describing a 24-year-old woman with a unilateral, systematized nevus across the left side of her body, and proposed that the disorder was due to a mutation during the cell cleavage stage of development.Based on this hypothesis, Zlotnikov suggested that the only probable explanation for the sagittal asymmetry of the disease was a genetic mosaicism in the patient.[2] However, this proposal was not widely explored until re-hypothesized by German dermatologist Rudolf Happle in the 1970s[16] due to the state of genetic and medical research in the Soviet Union at the time, and recent end of World War II.Jackson wished to inspire interaction between dermatologists who saw Blaschko's lines in patients, and developmental biologists studying embryology and chromosomal abnormalities such as mosaicism.