Adrenochrome
[1] The oxidation reaction that converts adrenaline into adrenochrome occurs both in vivo and in vitro.[4] Several small-scale studies (involving 15 or fewer test subjects) conducted in the 1950s and 1960s reported that adrenochrome triggered psychotic reactions such as thought disorder and derealization.[5] In 1954, researchers Abram Hoffer and Humphry Osmond claimed that adrenochrome is a neurotoxic, psychotomimetic substance and may play a role in schizophrenia and other mental illnesses.[10] Multiple additional studies in the United States,[11] Canada,[12] and Australia[13] similarly failed to find benefits of megavitamin therapy to treat schizophrenia.[citation needed] In the early 2000s, interest was renewed by the discovery that adrenochrome may be produced normally as an intermediate in the formation of neuromelanin.
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