[8] The regiment returned to England in June 1759 severely reduced in numbers by men drafted to other units and by tropical disease.[10] As unrest grew the 64th took place in an incident which lays a claim to the first blood of the American War of Independence being shed in Salem, Massachusetts.[16] Remaining in Philadelphia over the winter and into 1778, the 64th and 2nd Grenadier Battalion formed part of the rearguard when Lieutenant-General Clinton evacuated the city in June 1778.[19] After the capture of Charleston, the grenadier and light companies were withdrawn to New York and as Major-General Cornwallis began to advance on Virginia, the 64th remained in Carolina as guard troops.Back in England, a change occurred in army policy, to hopefully increase recruiting, infantry regiments were given additional territorial titles.[27] A short period as garrison duty followed and then the regiment returned to England, severely weakened by both losses in battle and sickness, mostly yellow fever.[28] Within months the 64th had returned to the West Indies for a campaign of seizing islands held by, variously, France, The Netherlands and Denmark.In the interim there had been a short spell in England, a long posting in Gibraltar, several years in Ireland, another six-year tour in the West Indies — where once again fever caused much suffering.[35] On the voyage home two companies, under the command of Captain James Draper, and about 100 women and children were on board the barque Alert when the ship hit a reef about 100 miles out of Halifax.The master of the Alert decided that the only course of action was to beach the vessel but was worried that the ship was becoming top heavy as the troops and their families made for the upper deck.[37] War between Britain and Persia broke out in 1856 and the 64th, together with the 20th Bombay Native Infantry, formed the 1st Brigade in the expeditionary force assembled for the campaign.[38] In 1857 the force advanced inland and defeated the Persian field army at Koosh-Ab on 8 February 1857 while the flank companies were involved in action at Ahwaz.[41][42] The regiment was immediately ordered to take part in the Cawnpore relief force under Major-General Sir Henry Havelock.[45] This award created considerable discontent within the 64th as the citation inferred that it was only due to Lt Havelock's actions that the regiment advanced and achieved its objectives.In 1874, as part of the Cardwell Reforms, line infantry battalions were linked in pairs,[51] and the 64th formed a joint depot with the 98th (Prince of Wales's) Regiment of Foot at Limerick.