Substituted tryptamine
Well-known tryptamines include serotonin, an important neurotransmitter, and melatonin, a hormone involved in regulating the sleep-wake cycle.Tryptamine alkaloids are found in fungi, plants and animals; and sometimes used by humans for the neurological or psychotropic effects of the substance.[19][20][21] α-Alkylation of tryptamine makes it much more metabolically stable and resistant to degradation by monoamine oxidase, resulting in increased potency and greatly lengthened half-life.[19][20][21] The most well-known of these agents are α-methyltryptamine (αMT) and α-ethyltryptamine (αET), both of which were used clinically as antidepressants for a brief period of time in the past and are abused as recreational drugs.Like tryptamines, these related compounds are primarily active as agonists at the 5-HT2 family of serotonin receptors, with applications in the treatment of glaucoma, cluster headaches, or as anorectics.
organic compoundstryptamineindoleamino (NH2) groupsidechainserotoninneurotransmittermelatoninhormonealkaloidsplantsanimalshumanspsychotropicpsilocybinpsilocybin mushroomschacrunaayahuascasyntheticmigrainesumatriptanpsychedelic drugsibogainemitragynineyohimbineAlexander ShulginTiHKAL2-HO-NMT5-MeO-NMTNω-MethylserotoninBufoteninBufotenidineO=C-CH3N-Acetylserotonin6-Hydroxymelatonin4-HO-NMTPsilocinNorbaeocystinBaeocystinAeruginascinLespedamine5-MeO-DMT5-Bromo-DMT6-Bromotryptamine5,6-Dibromotryptamine5,6-Dibromo-NMT5,6-Dibromo-DMTDesformylflustrabromineConvolutindole AAcetryptine5-(Nonyloxy)tryptamine2-Methyl-5-hydroxytryptamine5-MeO-T-NBOMe5-MeO-NBpBrTIdalopirdine4-HO-pyr-T5-MeO-pyr-TCH2CH2CH3CH(CH3)2H2C=CH-CH22-Methyl-DMT2-Me-DET4-MeO-DMT4-MeO-MiPT4-AcO-DMT4-PrO-DMT4-HO-MET4-Acetoxy-MET4-HO-DET4-Acetoxy-DET4-PO-DET4-HO-EPT4-HO-MPT4-HO-MiPT4-Acetoxy-MiPT4-HO-MALT4-HO-NALT4-HO-EiBT4-HO-McPT4-HO-McPeT4-HO-DPT4-AcO-DPT4-HO-PiPT4-HO-DIPT4-Acetoxy-DiPTFT-1044-AcO-DALT4-HO-DBT4-HO-DSBT5-MeO-MET5-MeO-DET5-MeO-EPT5-MeO-DPT5-MeO-MALT5-MeO-DALT5-MeO-MiPT5,6-MeO-MiPT5-MeO-EiPT5-MeO-PiPT5-MeO-DIPT5-MeO-DBT5-MeS-DMT5-AcO-DMT5-Ethoxy-DMT5-HO-DiPT5,N,N-TMT5-Ethyl-DMT5-Fluoro-DMT5-Fluoro-MET5-Fluoro-DET5-Fluoro-EPT5-Chloro-DMT5-TFM-DMT5-TFMO-DMT5-Nitro-DMTAlmotriptanRizatriptanZolmitriptan6-Fluoro-DMT6-Fluoro-DET7-Methyl-DMT1-MethylpsilocinNBoc-DMT5-MeO-2-TMT5-Methoxy-7,N,N-trimethyltryptamine4-HO-5-MeO-DMT